Among the five, Eric Bailly, Alex Telles and Anthony Martial are perhaps the only ones who would have been assured of a starting role. Apart from the five, Ole Gunnar Solskjaer has an otherwise fit squad to choose from ahead of the match.
The Norwegian is likely to retain the diamond formation that worked impressively against RB Leipzig in the Champions League as United secured a huge 5-0 win in midweek.
Whereas using two strikers increases the chances of Edinson Cavani making his first Premier League start, it is likely Solskjaer could prefer the pairing of Mason Greenwood and Marcus Rashford.
Such a move would see Cavani drop to the bench with a chance of coming on as a late substitute.
Bruno Fernandes is sure to make a return to the starting line up, playing in the most advanced role ahead of Donny van de Beek and Juan Mata.
The trio of Scott McTominay, Fred and Paul Pogba are expected to take positions behind Fernandes, with Nemanja Matic dropping to the bench.
Despite previously insisting on the importance of managing the fitness of defensive duo Aaron Wan-Bissaka and Luke Shaw, it is expected that the full backs will get the not to start on either side of the flanks.
David de Gea will undoubtedly keep his place between the sticks, with Dean Henderson only making the bench.
The fixture will see United seek to continue their dominance over Arsenal at Old Trafford, with the Gunners yet to win at the Theatre of Dreams since 2015.
Only two points separate the two sides on the charts even as they sit on the bottom half of the standings after an underwhelming start to the season.