Saints have been hit-and-miss this season so far but seem to be on an upward path of late after three in a row without defeat.
Danny Ings has continued his brilliant form of 2020 into this season – but that is matched by Dominic Calvert-Lewin for the opposition.
The Toffees dropped their first points of the campaign at home to Merseyside rivals Liverpool last weekend, while Southampton snatched a dramatic late 3-3 draw with Chelsea.
So far Everton have mostly relied on scoring more than their opposition, but Southampton have kept more Premier League clean sheets against Everton than they have against any other team in the competition – 13, 10 of which have come at home.
Southampton possible starting lineup:
McCarthy; Walker-Peters, Bednarek, Vestergaard, Bertrand; Armstrong, Ward-Prowse, Romeu, Redmond; Ings, Adams
Everton possible starting lineup:
Pickford; Godfrey, Mina, Keane, Digne; Doucoure, Allan, Gomes; Rodriguez, Calvert-Lewin, Iwobi